Distemper canino y su impacto en la fauna doméstica y silvestre

Autores/as

  • Emilio Sebastián Patiño Balcazar Medicina Veterinaria, Facultad de Ciencias Agropecuarias, Grupo de Investigación de Salud Animal, Universidad Técnica de Ambato, Tungurahua, Ecuador https://orcid.org/0009-0004-6682-9388
  • Diana Avilés-Esquivel Medicina Veterinaria, Facultad de Ciencias Agropecuarias, Grupo de Investigación de Salud Animal, Universidad Técnica de Ambato, Tungurahua, Ecuador. https://orcid.org/0000-0002-4319-6053

DOI:

https://doi.org/10.30972/vet.3719102

Palabras clave:

virus del distemper canino, fauna silvestre, Canis lupus familiaris, Morbillivirus

Resumen

La infección por el virus del distemper canino (VDC) constituye uno de los problemas sanitarios más relevantes en medicina veterinaria debido a su elevada capacidad de contagio, su notable diversidad genética y su impacto simultáneo en la fauna doméstica y silvestre. Esta revisión compiló información reciente sobre distintos aspectos del VDC, abarcando su etiología, transmisión, reservorios, impacto clínico y ecológico, así como los avances diagnósticos, las estrategias de prevención y las alternativas terapéuticas. Los estudios epidemiológicos muestran que los perros domésticos continúan siendo el principal foco de transmisión, especialmente cuando no cuentan con inmunización adecuada; sin embargo, numerosas especies silvestres incluyendo cánidos, félidos, mustélidos, úrsidos y prociónidos actúan como reservorios y amplificadores, favoreciendo la persistencia del virus en diversos ecosistemas. Además, la variabilidad genética del VDC, particularmente en el gen H, influye en su tropismo y patogenicidad, facilitando la emergencia de linajes con mayor capacidad de afectar el sistema nervioso o cruzar barreras interespecie. Los avances diagnósticos como la RT-qPCR y la secuenciación genómica han permitido detectar mutaciones relevantes y mejorar la vigilancia molecular. Por otro lado, las estrategias preventivas basadas en vacunas atenuadas y recombinantes han demostrado alta eficacia en perros y algunas especies silvestres, aunque su respuesta es variable según el hospedador. Las nuevas aproximaciones terapéuticas como las nanopartículas de plata o los inhibidores metabólicos representan alternativas prometedoras que podrían mejorar la supervivencia en animales afectados. En conjunto, la evidencia disponible confirma que el VDC persiste como una amenaza multiespecie cuya dinámica depende de la interacción entre perros domésticos y fauna silvestre, lo que refuerza la necesidad de fortalecer la vigilancia molecular y optimizar las estrategias de prevención para mitigar sus repercusiones sanitarias y ecológicas.

Descargas

Los datos de descargas todavía no están disponibles.

Citas

1. Alfano F, Lanave G, Lucibelli MG, Miletti G, D'Alessio N, Gallo A, Auriemma C, Amoroso MG, Lucente MS, De Carlo E, Martella V, Decaro N, Fusco G. canine distemper virus in autochtonous and imported dogs, Southern Italy (2014-2021). Animals (Basel). 2022; 12(20): 2852.

2. Alfano F, Lucibelli MG, D'Alessio N, Auriemma C, Rea S, Sgroi G, Lucente MS, Pellegrini F, Diakoudi G, De Carlo E, Decaro N, Lanave G, Martella V, Fusco G. Detection of canine distemper virus in wildlife in Italy (2022-2024). Front Vet Sci. 2025; 12: 1527550.

3. Almberg ES, Mech LD, Smith DW, Sheldon JW, Crabtree RL. A serological survey of infectious disease in Yellowstone National Park's canid community. PLoS One. 2009; 4: e7042.

4. Armstrong WH, Anthony CH. An epizootic of canine distemper in a zoological park. Cornell Vet. 1942; 32: 286-288.

5. Balseiro A, Herrero-García G, García Marín JF, Balsera R, Monasterio JM, Cubero D, de Pedro G, Oleaga Á, García-Rodríguez A, Espinoza I, Rabanal B, Aduriz G, Tuñón J, Gortázar C, Royo LJ. New threats in the recovery of large carnivores inhabiting human-modified landscapes: the case of the Cantabrian brown bear (Ursus arctos). Vet Res. 2024; 55(1): 24.

6. Beineke A, Puff C, Seehusen F, Baumgärtner W. Pathogenesis and immunopathology of systemic and nervous canine distemper. Vet Immunol Immunopathol. 2009; 127(1-2): 1-18.

7. Beineke A, Baumgärtner W, Wohlsein P. Cross-species transmission of canine distemper virus-an update. One Health. 2015; 1: 49-59.

8. Belsare AV, Vanak AT, Gompper ME. Epidemiology of viral pathogens of free-ranging dogs and Indian foxes in a human-dominated landscape in central India. Transbound. Emerg. Dis. 2014; 61: 78-86.

9. Bodgener J, Sadaula A, Thapa PJ, Shrestha BK, Gairhe KP, Subedi S, Rijal KR, Pandey P, Joshi JD, Kandel P, Lamichane BR, Pokheral CP, Subedi N, Kandel RC, Luitel H, Techakriengkrai N, Gilbert M. Canine distemper virus in tigers (Panthera tigris) and leopards (P. pardus) in Nepal. Pathogens. 2023; 12(2): 203.

10. Bush M, Montali RJ, Brownstein D, James AE, Appel MJ. Vaccine-induced canine distemper in a lesser panda. J. Am. Vet. Med. Assoc. 1976; 169: 959-960.

11. Castellanos-Peñafiel AX, Yánez-Zapata AE, Carrillo J, Castellanos-Insuasti FX, Arias-Cárdenas L. First report of canine distemper in the Andean fox (Lycalopex culpaeus) in Ecuador. Boletín Técnico, Serie Zoológica. 2020; 15(16): 5-9.

12. Castellanos AX, Medina MQ, Beltrán DV. Virus in an Andean bear. Boletín Técnico, Serie Zoológica. 2023; 18:05-08.

13. Chludzinski E, Klemens J, Ciurkiewicz M, Geffers R, Pöpperl P, Stoff M, Shin DL, Herrler G, Beineke A. Phenotypic and transcriptional changes of pulmonary immune responses in dogs following canine distemper virus infection. Int J Mol Sci. 2022; 23(17): 10019.

14. Coradduzza E, Stefania FM, Pintus D, Ferretti L, Ledda A, Chessa GS, Rocchigiani AM, Lostia G, Rossi R, Cancedda MG, Macciocu S, Cherchi M, Denurra D, Pintore A, Bechere R, Pudda F, Muzzeddu M, Dettori MA, Ruiu A, Puggioni G. Canine distemper virus in Sardinia, Italy: detection and phylogenetic analysis in foxes. Animals (Basel). 2024; 14(21): 3134.

15. Cypher BL, Scrivner JH, Hammer KL, O'Farrell TP. Viral antibodies in coyotes from California. J. Wildl. Dis. 1998; 34: 259-264.

16. Da Costa VG, Saivish MV, Rodrigues RL, de Lima Silva RF, Moreli ML, Krüger RH. Molecular and serological surveys of canine distemper virus: a meta-analysis of cross-sectional studies. PLoS One. 2019; 14(6): e0217594.

17. de Almeida Curi NH, Coelho CM, de Campos Cordeiro Malta M, Magni EM, Sábato MA, Araújo AS, Lobato ZI, Santos JL, Santos HA, Ragozo AA, de Souza SL Pathogens of wild maned wolves (Chrysocyon brachyurus) in Brazil. J. Wildl. Dis. 2012; 48: 1052-1056.

18. Di Francesco CE, Gentile L, Di Pirro V, Ladiana L, Tagliabue S, Marsilio F. Serologic evidence for selected infectious diseases in Marsican brown bears (Ursus arctos marsicanus) in Italy (2004–09). J. Wildl. Dis. 2015; 51: 209-213.

19. Di Francesco CE, Smoglica C, Angelucci S. Infectious Diseases and Wildlife Conservation Medicine: The Case of the Canine Distemper in European Wolf Population. Animals (Basel). 2020; 10(12): 2426.

20. Di Sabatino D, Lorusso A, Di Francesco CE, Gentile L, Di Pirro V, Bellacicco AL, Giovannini A, Di Francesco G, Marruchella G, Marsilio F, Savini G. Arctic lineage-canine distemper virus as a cause of death in Apennine wolves (Canis lupus) in Italy. PLoS One. 2014; 9.

21. Dorji T, Tenzin T, Tenzin K, Tshering D, Rinzin K, Phimpraphai W, de Garine-Wichatitsky M. Seroprevalence and risk factors of canine distemper virus in the pet and stray dogs in Haa, western Bhutan. BMC Vet Res. 2020; 16(1): 135.

22. Duque-Valencia J, Sarute N, Olarte-Castillo XA, Ruíz-Sáenz J. Evolution and interspecies transmission of canine distemper virus-an outlook of the diverse evolutionary landscapes of a multi-host virus. Viruses. 2019; 11(7): 582.

23. Ferreyra H, Calderón MG, Marticorena D, Marull C, Leonardo BC. Canine distemper infection in crab-eating fox (Cerdocyon thous) from Argentina. J. Wildl. Dis. 2009; 45: 1158-1162.

24. Foley JE, Swift P, Fleer KA, Torres S, Girard YA, Johnson CK. Risk factors for exposure to feline pathogens in California mountain lions (Puma concolor). J Wildl Dis. 2013:279-93.

25. Furtado MM, de Ramos Filho JD, Scheffer KC, Coelho CJ, Cruz PS, Ikuta CY, Jácomo AT, Porfírio GE, Silveira L, Sollmann R, Tôrres NM, Ferreira Neto JS. Serosurvey for selected viral infections in free-ranging jaguars (Panthera onca) and domestic carnivores in Brazilian Cerrado, Pantanal, and Amazon. J. Wildl. Dis. 2013; 49: 510-521.

26. Furtado MM, Hayashi EM, Allendorf SD, Coelho CJ, de Almeida Jácomo AT, Megid J, Ramos Filho JD, Silveira L, Tôrres NM, Ferreira Neto JS. Exposure of free-ranging wild carnivores and domestic dogs to canine distemper virus and parvovirus in the Cerrado of Central Brazil. Ecohealth. 2016; 13(3): 549-557.

27. Gastelum-Leyva F, Pena-Jasso A, Alvarado-Vera M, Plascencia-López I, Patrón-Romero L, Loera-Castañeda V, Gándara-Mireles JA, Lares-Asseff I, Leal-Ávila MÁ, Alvelais-Palacios JA, Almeida-Pérez J, Bogdanchikova N, Pestryakov A, Almanza-Reyes H. Evaluation of the efficacy and safety of silver nanoparticles in the treatment of non-neurological and neurological distemper in dogs: a randomized clinical trial. Viruses. 2022; 14(11): 2329.

28. Gehrt SD, Kinsel MJ, Anchor C. Pathogen dynamics and morbidity of striped skunks in the absence of rabies. J. Wildl. Dis. 2010; 46: 335-347.

29. Geng Y, Shen F, Wu W, Zhang L, Luo L, Fan Z, Hou R, Yue B, Zhang X. First demonstration of giant panda’s immune response to canine distemper vaccine. Dev Comp Immunol. 2020; 102: 103489.

30. Georoff TA, Ramsay EC, Gyimesi ZS, Kilburn JJ, Sykes JM 4th. Review of canine distemper vaccination use and safety in north American captive large felids (Panthera spp.) from 2000 to 2017. J Zoo Wildl Med. 2020; 50(4): 778-789.

31. Gese EM, Schultz RD, Johnson MR, Williams ES, Crabtree RL, Ruff RL. Serological survey for diseases in free-ranging coyotes (Canis latrans) in Yellowstone National Park, Wyoming. J. Wildl. Dis. 1997; 33: 47-56.

32. Giannitti F, Diab SS, Uzal FA, Fresneda K, Rossi D, Talmi-Frank D, Baneth G. Infection with a Hepatozoon sp. closely related to Hepatozoon felis in a wild Pampas gray fox (Lycalopex–Pseudalopex-gymnocercus) co-infected with canine distemper virus. Vet. Parasitol. 2012; 186: 497-502.

33. Gilbert M, Sulikhan N, Uphyrkina O, Goncharuk M, Kerley L, Castro EH, Reeve R, Seimon T, McAloose D, Seryodkin IV, Naidenko SV, Davis CA, Wilkie GS, Vattipally SB, Adamson WE, Hinds C, Thomson EC, Willett BJ, Hosie MJ, Logan N, McDonald M, Ossiboff RJ, Shevtsova EI, Belyakin S, Yurlova AA, Osofsky SA, Miquelle DG, Matthews L, Cleaveland S. Distemper, extinction, and vaccination of the Amur tiger. Proc Natl Acad Sci U S A. 2020; 117(50): 31954-31962.

34. Goller KV, Fyumagwa RD, Nikolin V, East ML, Kilewo M, Speck S, Müller T, Matzke M, Wibbelt G. Fatal canine distemper infection in a pack of African wild dogs in the Serengeti ecosystem, Tanzania. Vet. Microbiol. 2010; 146: 245-252.

35. Gordon CH, Banyard AC, Hussein A, Laurenson MK, Malcolm JR, Marino J, Regassa F, Stewart AME, Fooks AR, Sillero-Zubiri C. Canine distemper in endangered Ethiopian wolves. Em Inf Dis. 2015; 21: 824-831.

36. Gowtage-Sequeira S, Banyard AC, Barrett T, Buczkowski H, Funk SM, Cleaveland S. Epidemiology, pathology, and genetic analysis of a canine distemper epidemic in Namibia. J. Wildl. Dis. 2009; 45: 1008-1020.

37. Halbrooks RD, Swango LJ, Schurrenberger RP, Mitchell FE, Hill EP. Response of gray foxes to modified-live virus canine distemper vaccine. J. Am. Vet. Med. Assoc. 1981; 179: 1170-1174.

38. Hassenin ASH, Durrani A. Sensitivity & specificity of ELISA kit for antibody detection of canine parvovirus and canine distemper infection in dogs. Mathews J Vet Sci. 2023; 7(6): 34.

39. Hedrick PW, Lee RN, Buchanan C. Canine parvovirus enteritis, canine distemper, and major histocompatibility complex genetic variation in Mexican wolves. J. Wildl. Dis. 2003; 39: 909-913.

40. Hvistendahl M. Endangered species. Captive pandas succumb to killer virus. Science. 2015; 347: 700-701.

41. Johnson KL, Craig LE, Wilson S, McLarty E, Hespel AM. Radiographic evidence of metaphyseal sclerosis secondary to canine distemper virus: 4 cases in juvenile dogs. J Vet Intern Med. 2022; 36(4): 1303-11.

42. Kazacos KR, Thacker HL, Shivaprasad HL, Burger PP. Vaccination-induced distemper in kinkajous. J. Am. Vet. Med. Assoc. 1981; 179: 1166-1169.

43. Kennedy JM, Earle JAP, Omar S, Abdullah H, Nielsen O, Roelke-Parker ME, Cosby SL. Canine and phocine distemper viruses: global spread and genetic basis of jumping species barriers. Viruses. 2019; 11(10): 944.

44. Kim DY, Zinn MM, Odemuyiwa SO, Mitchell WJ Jr, Johnson GC. Myocarditis caused by naturally acquired canine distemper virus infection in 4 dogs. J Vet Diagn Invest. 2021; 33(1): 167-169.

45. Kimpston CN, Hatke AL, Castelli B, Otto N, Tiffin HS, Machtinger ET, Brown JD, Van Why KR, Marconi RT. High prevalence of antibodies against canine parvovirus and canine distemper virus among coyotes and foxes from Pennsylvania: implications for the intersection of companion animals and wildlife. Microbiol Spectr. 2022; 10(4): e0253221.

46. Kirk CM, Amstrup S, Swor R, Holcomb D, O'Hara TM. Morbillivirus and Toxoplasma exposure and association with hematological parameters for southern Beaufort Sea polar bears: potential response to infectious agents in a sentinel species. Ecohealth. 2010; 7: 321-331.

47. Lanszki Z, Tóth GE, Schütz É, Zeghbib S, Rusvai M, Jakab F, Kemenesi G. Complete genomic sequencing of canine distemper virus with nanopore technology during an epizootic event. Sci Rep. 2022; 12(1): 4160.

48. Lempp C, Spitzbarth I, Puff C, Cana A, Kegler K, Techangamsuwan S, Baumgärtner W, Seehusen F. New aspects of the pathogenesis of canine distemper leukoencephalitis. Viruses. 2014; 6(7): 2571-601.

49. Li Y, Yi L, Cheng S, Wang Y, Wang J, Sun J, Zhang Q, Xu X. Inhibition of canine distemper virus replication by blocking pyrimidine nucleotide synthesis with A77 1726, the active metabolite of the anti-inflammatory drug leflunomide. J Gen Virol. 2021; 102(3): 001534.

50. Liang J, Wang T, Wang Q, Wang X, Fan X, Hu T, Leng X, Shi K, Li J, Gong Q, Du R. Prevalence of canine distemper in minks, foxes and raccoon dogs from 1983 to 2023 in Asia, North America, South America and Europe. Front Vet Sci. 2024; 11: 1394631.

51. Loots AK, Mitchell E, Dalton DL, Kotzé A, Venter EH. Advances in canine distemper virus pathogenesis research: a wildlife perspective. J Gen Virol. 2017; 98(3): 311-321.

52. Ludlow M, Nguyen DT, Silin D, Lyubomska O, de Vries RD, von Messling V, McQuaid S, De Swart RL, Duprex WP. Recombinant canine distemper virus strain Snyder Hill expressing green or red fluorescent proteins causes meningoencephalitis in the ferret. J. Virol. 2012; 86: 7508-7519.

53. Lunardi M, Darold GM, Amude AM, Headley SA, Sonne L, Yamauchi KCI, Boabaid FM, Alfieri AF, Alfieri AA. Canine distemper virus active infection in order Pilosa, family Myrmecophagidae, species Tamandua tetradactyla. Vet Microbiol. 2018; 220: 7-11.

54. Macías-González J, Granado-Gil R, Mendoza-González L, Pedroza-Roldán C, Alonso-Morales R, Realpe-Quintero M. Canine distemper virus in Mexico: a risk factor for wildlife. Viruses. 2025; 17(6): 813.

55. Martino PE, Montenegro JL, Preziosi JA, Venturini C, Bacigalupe D, Stanchi NO, Bautista EL. Serological survey of selected pathogens of free-ranging foxes in southern Argentina, 1998–2001. Rev. Sci. Tech. 2004; 23: 801-806.

56. Martinez-Gutierrez M, Ruiz-Saenz J. Diversity of susceptible hosts in canine distemper virus infection: a systematic review and data synthesis. BMC Vet Res. 2016; 12: 78.

57. McDermott I, Gilbert M, Shah MK, Sadaula A, Anderson NE. Seroprevalence of canine distemper virus (CDV) in the free-roaming dog (Canis familiaris) population surrounding Chitwan National Park, Nepal. PLoS One. 2023; 18(2): e0281542.

58. McFadden KW, Wade SE, Dubovi EJ, Gompper ME. A serological and fecal parasitologic survey of the critically endangered pygmy raccoon (Procyon pygmaeus) J. Wildl. Dis. 2005; 41: 615-617.

59. McInnes EF, Burroughs RE, Duncan NM. Possible vaccine-induced canine distemper in a South American bush dog (Speothos venaticus) J. Wildl. Dis. 1992; 28: 614-617.

60. Megid J, Teixeira CR, Amorin RL, Cortez A, Heinemann MB, de Paula Antunes JM, da Costa LF, Fornazari F, Cipriano JR, Cremasco A, Richtzenhain LJ. First identification of canine distemper virus in hoary fox (Lycalopex vetulus): pathologic aspects and virus phylogeny. J. Wildl. Dis. 2010; 46: 303-305.

61. Miller DS, Covell DF, McLean RG, Adrian WJ, Niezgoda M, Gustafson JM, Rongstad OJ, Schultz RD, Kirk LJ, Quan TJ. Serologic survey for selected infectious disease agents in swift and kit foxes from the western United States. J. Wildl. Dis. 2000; 36: 798-805.

62. Mohammad HA, Ajaj EA, Gharban HAJ. The first study on confirmation and risk factors of acute and chronic canine distemper in stray dogs in Wasit Province, Iraq, using enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction. Vet World. 2022; 15(4): 968-74.

63. Mousafarkhani F, Sarchahi AA, Mohebalian H, Khoshnegah J, Arbabi M. Prevalence of canine distemper in dogs referred to Veterinary Hospital of Ferdowsi University of Mashhad, Mashhad, Iran. Vet Res Forum. 2023; 14(3): 153-160.

64. Müller A, Silva E, Santos N, Thompson G. Domestic dog origin of canine distemper virus in free-ranging wolves in Portugal as revealed by hemagglutinin gene characterization. J. Wildl. Dis. 2011; 47: 725-729.

65. Nagao Y, Nishio Y, Shiomoda H, Tamaru S, Shimojima M, Goto M, Une Y, Sato A, Ikebe Y, Maeda K. An outbreak of canine distemper virus in tigers (Panthera tigris): possible transmission from wild animals to zoo animals. J. Vet. Med. Sci. 2012; 74: 699-705.

66. Nava AF, Cullen L Jr, Sana DA, Nardi MS, Filho JD, Lima TF, Abreu KC, Ferreira F. First evidence of canine distemper in Brazilian free-ranging felids. Ecohealth. 2008; 5(4): 513-8.

67. Nouvellet P, Donnelly CA, De Nardi M, Rhodes CJ, De Benedictis P, Citterio C, Obber F, Lorenzetto M, Pozza MD, Cauchemez S, Cattoli G. (2013) Rabies and Canine Distemper Virus Epidemics in the Red Fox Population of Northern Italy (2006–2010). PLoS ONE 8(4): e61588. https://doi.org/10.1371/journal.pone.0061588

68. .Oleaga Á, Vázquez CB, Royo LJ, Barral TD, Bonnaire D, Armenteros JÁ, Rabanal B, Gortázar C, Balseiro A. Canine distemper virus in wildlife in south-western Europe. Transbound Emerg Dis. 2022; 69(5): e473-85.

69. Oliver Guimera A. On the pathogenesis and shifting dynamics of canine distemper infection in dogs and wild carnivores. Tesis de doctorado en Doctor en filosofía, Universidad de California. 2023.

70. Origgi FC, Plattet P, Sattler U, Robert N, Casaubon J, Mavrot F, Pewsner M, Wu N, Giovannini S, Oevermann A, Stoffel MH, Gaschen V, Segner H, Ryser-Degiorgis MP. Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores. Vet. Pathol. 2012; 49: 913-929.

71. Philippa JD, Leighton FA, Daoust PY, Nielsen O, Pagliarulo M, Schwantje H, Shury T, Van Herwijnen R, Martina BE, Kuiken T, Van de Bildt MW, Osterhaus AD. Antibodies to selected pathogens in free-ranging terrestrial carnivores and marine mammals in Canada. Vet. Rec. 2004; 155: 135-140.

72. Pinotti MA. Distemper canino: evaluación de dos alternativas terapéuticas y caracterización de aspectos clínico-epidemiológicos en la ciudad de Santa Fe, durante los años 1998-2009 Tesis de Maestría en Ciencias Veterinarias, Universidad Nacional del Litoral. 2011.

73. Pope JP, Miller DL, Riley MC, Anis E, Wilkes RP. Characterization of a novel canine distemper virus causing disease in wildlife. J Vet Diagn Invest. 2016; 28(5): 506-13.

74. Qiu W, Zheng Y, Zhang S, Fan Q, Liu H, Zhang F, Wang W, Liao G, Hu R. Canine distemper outbreak in rhesus monkeys, China. Emerg Infect Dis. 2011; 17(8): 1541-3.

75. Rentería-Solís Z, Förster C, Aue A, Wittstatt U, Wibbelt G, König M. Canine distemper outbreak in raccoons suggests pathogen interspecies transmission amongst alien and native carnivores in urban areas from Germany. Vet. Microbiol. 2014; 174: 50-99.

76. Rendon-Marin S, da Fontoura Budaszewski R, Canal CW, Ruiz-Saenz J. Tropism and molecular pathogenesis of canine distemper virus. Virol J. 2019; 16(1): 30.

77. Rendon-Marin S, Higuita-Gutiérrez LF, Ruiz-Saenz J. Safety and immunogenicity of Morbillivirus canis vaccines for domestic and wild animals: a scoping review. Viruses. 2024; 16(7): 1078.

78. Rivera-Martínez A, Rodríguez-Alarcón CA, Adame-Gallegos JR, Laredo-Tiscareño SV, de Luna-Santillana EJ, Hernández-Triana LM, Garza-Hernández JA. Canine distemper virus: origins, mutations, diagnosis, and epidemiology in Mexico. Life (Basel). 2024; 14(8): 1002.

79. Rodríguez-Cabo-Mercado R, Martínez-Hernández F, Aréchiga-Ceballos N, López-Díaz O, Muñoz-García CI, Aguilar-Setién A, Villalobos G, Villanueva-García C, Verdugo-Rodríguez A, Iturbe-Ramírez R, Rendón-Franco E. Canine distemper in neotropical procyonids: Molecular evidence, humoral immune response and epidemiology. Virus Res. 2020; 290: 198164.

80. Roelke-Parker ME, Munson L, Packer C, Kock R, Cleaveland S, Carpenter M, O'Brien SJ, Pospischil A, Hofmann-Lehmann R, Lutz H, Mwamengele GL, Mgasa MN, Machange GA, Summers BA, Appel MJ. A canine distemper virus epidemic in Serengeti lions (Panthera leo). Nature. 1996; 379: 441-445.

81. Romanutti C, Keller L, Boado L, La Torre J, Gallo Calderón MB. Primer aislamiento de una cepa salvaje de virus distemper canino en Argentina. Congreso Argentino de Virología. 2017.

82. Saeidi E, Kheradmand F. Canine distemper virus (CDV) in grey wolf (Canis lupus) in Fars Province of Iran. Vet Ital. 2023; 59(1).

83. Santos BPCR, Joaquim JGF, Cassu RN, Pantoja JCF, Luna SPL. Effects of acupuncture in the treatment of dogs with neurological sequels of distemper virus. J Acupunct Meridian Stud. 2022; 15(4): 238-246.

84. Sarchahi AA, Mohebalian H, Arbabi M. Evaluation of Newcastle disease virus vaccine effectiveness in dogs with neurological signs of canine distemper. Vet Res Forum. 2022; 13(4): 563-568.

85. Schönbauer M, Kölbl S, Schönbauer-Längle A. Perinatale Staupeinfektion bei drei Eisbären (Ursus maritimus) und bei einem Brillenbären (Tremarctos ornatus) Verhandlungsbericht Int. Symp. Erkrankungen Zootiere. 1984; 26: 131-136.

86. Selleck MR, Johnson SR, Gilbert AT. Serological response to canine distemper vaccination in wild caught raccoons (Procyon lotor). J Zoo Wildl Med. 2024; 55(2): 462-5.

87. Shamir M, Yakobson B, Baneth G, King R, Dar-Verker S, Markovics A, Aroch I. Antibodies to selected canine pathogens and infestation with intestinal helminths in golden jackals (Canis aureus) in Israel. Vet. J. 2001; 162: 66-72.

88. Shi N, Zhang L, Yu X, Zhu X, Zhang S, Zhang D, Duan M. Insight Into an Outbreak of Canine Distemper Virus Infection in Masked Palm Civets in China. Front Vet Sci. 2021; 8: 728238.

89. Shi P, Wang Z, Sheng W, Wang Z, Wang S, Zhang C, Zhao L, Zou J, Zhou H. Whole-canine neutralizing antibodies generated by single B cell antibody technology elicit therapeutic protection against canine distemper virus infection. Vet Microbiol. 2025; 302: 110412.

90. Stancu AC, Voia OS, Boldura OM, Pasca SA, Luca I, Hulea AS, Ivan OR, Dragoescu AA, Lungu BC, Hutu I. Unusual canine distemper virus infection in captive raccoons (Procyon lotor). Viruses. 2023; 15(7): 1536.

91. Stephenson N, Higley JM, Sajecki JL, Chomel BB, Brown RN. Foley JE demographic characteristics and infectious diseases of a population of American black bears in Humboldt County, California. Vector Borne Zoonotic Dis. 2015; 15: 116-123.

92. Suwanpakdee S, Wiratsudakul A, Chaisilp N, Prasittichai L, Skulpong A, Maneeorn P, Bhusri B, Mongkolpan C, Buddhirongawatr R, Taowan J, Wongluechai P, Arya N, Suwannaprapha P, Ngamwongsatit N, Wiriyarat W, Sangkachai N. Canine distemper outbreak and laryngeal paralysis in captive tigers (Panthera tigris). BMC Vet Res. 2025; 21(1): 33.

93. Tatsuo H, Yanagi Y. The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 2002; 46(3): 135-42.

94. Terio KA, Craft ME. Canine distemper virus (CDV) in another big cat: should CDV be renamed carnivore distemper virus? mBio. 2013; 4: e00702-e00713.

95. Thalwitzer S, Wachter B, Robert N, Wibbelt G, Müller T, Lonzer J, Meli ML, Bay G, Hofer H, Lutz H. Seroprevalences to viral pathogens in free-ranging and captive cheetahs (Acinonyx jubatus) on Namibian Farmland. Clin. Vaccine Immunol. 2010; 17: 232-238.

96. Timm SF, Munson L, Summers BA, Terio KA, Dubovi EJ, Rupprecht CE, Kapil S, Garcelon DK. A suspected canine distemper epidemic as the cause of a catastrophic decline in Santa Catalina Island foxes (Urocyon littoralis catalinae) J. Wildl. Dis. 2009; 45: 333-343.

97. Tonchiangsai K, Wiratsudakul A, Kasemsuwan S, Buddhirongawatr R, Thanapongtharm W, Kledmanee K, Chamsai T, Sangkachai N, Sangkharak B, Aramsirirujiwet P, Suwanpakdee S. Quantitative risk assessment and interventional recommendations for preventing canine distemper virus infection in captive tigers at selected wildlife stations in Thailand. PLoS One. 2025; 20(4): e0320657.

98. Trebbien R, Chriel M, Struve T, Hjulsager CK, Larsen G, Larsen LE. Wildlife reservoirs of canine distemper virus resulted in a major outbreak in Danish farmed mink (Neovison vison). PLoS One. 2014; 9.

99. Trogu T, Castelli A, Canziani S, Tolini C, Carrera M, Sozzi E, Lelli D, Tosi G, Fiorentini L, Di Donato A, Rugna G, Lanci D, Lavazza A, Moreno A. Detection and molecular characterization of canine distemper virus in wildlife from Northern Italy. Pathogens. 2022; 11(12): 1557.

100. van Moll P, Alldinger S, Baumgärtner W, Adami M. Distemper in wild carnivores: an epidemiological, histological and immunocytochemical study. Vet. Microbiol. 1995; 44: 193-199.

101. Vandevelde M, Zurbriggen A. Demyelination in canine distemper virus infection: a review. Acta Neuropathol. 2005; 109(1): 56-68.

102. Vega-Mariño P, Olson J, Howitt B, Criollo R, Figueroa L, Orlando SA, Cruz M, Garcia-Bereguiain MA. A recent distemper virus outbreak in the growing canine populations of Galapagos Islands: a persistent threat for the endangered Galapagos Sea Lion. Front Vet Sci. 2023; 10: 1154625.

103. Watson AM, Cushing AC, Sheldon JD, Anis E, Wilkes RP, Dubovi EJ, Craig LE. Natural canine distemper virus infection in Linnaeus's 2-Toed Sloths (Choloepus didactylus). Vet Pathol. 2020; 57(2): 311-315.

104. Wiener DJ, Welle MM, Origgi FC. Cutaneous lesions associated with dual infection caused by canine distemper virus and orthopoxvirus in a domestic cat. Vet. Dermatol. 2013; 24: 543-546.

105. Wilkes RP. Canine distemper virus in endangered species: species jump, clinical variations, and vaccination. Pathogens. 2023; 12(1): 57.

106. Wilkes RP, Sanchez E, Riley MC, Kennedy MA. Real-time reverse transcription polymerase chain reaction method for detection of canine distemper virus modified live vaccine shedding for differentiation from infection with wild-type strains. J Vet Diagn Invest. 2014; 26(1): 27-34.

107. Williams ES, Thorne ET, Appel MJ, Belitsky DW. Canine distemper in black-footed ferrets (Mustela nigripes) from Wyoming. J. Wildl. Dis. 1988; 24: 385-398.

108. Wipf A, Perez-Cutillas P, Ortega N, Huertas-López A, Martínez-Carrasco C, Candela MG. Geographical distribution of carnivore hosts and genotypes of canine distemper virus (CDV) worldwide: a scoping review and spatial meta-analysis. Transbound Emerg Dis. 2025; 2025(1): 6632068.

109. Woo GH, Jho YS, Bak EJ. Canine distemper virus infection in fennec fox (Vulpes zerda) J. Vet. Med. Sci. 2010; 72: 1075-1079.

110. Wostenberg DJ, Walker N, Fox KA, Spraker TR, Piaggio AJ, Gilbert A. Evidence of two cocirculating canine distemper virus strains in mesocarnivores from northern Colorado, USA. J Wildl Dis. 2018; 54(3): 534-543.

111. Wu Q, Tang L, Zhu Q, Jin X, Jin Y. Canine distemper and wildlife. Acta Theriol Sin. 2021; 41(3): 261-274.

112. Zhao J, Zhang H, Bai X, Martella V, Hu B, Sun Y, Zhu C, Zhang L, Liu H, Xu S, Shao X, Wu W, Yan X. Emergence of canine distemper virus strains with two amino acid substitutions in the haemagglutinin protein, detected from vaccinated carnivores in North-Eastern China in 2012–2013. Vet. J. 2014; 200: 191-194.

113. Zhao J, Shi N, Sun Y, Martella V, Nikolin V, Zhu C, Zhang H, Hu B, Bai X, Yan X. Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks. Antiviral Res. 2015; 122: 1-11.

Descargas

Publicado

2026-02-04

Cómo citar

Patiño Balcazar, E. S., & Avilés-Esquivel, D. (2026). Distemper canino y su impacto en la fauna doméstica y silvestre. Revista Veterinaria, 37(1), 1–14. https://doi.org/10.30972/vet.3719102

Número

Sección

Revisiones Bibliográficas