Parvovirus Equino-Hepatitis (EqPV-H): un nuevo virus contaminante de productos biológicos de origen veterinario

V. Ruiz; I. Alvarez

doi:10.30972/vet.3427058

Authors

V. Ruiz Laboratorio de Virus Adventicios, Instituto de Virología e Innovaciones Tecnológicas (IVIT) CICVyA, INTA Castelar. Consejo Nacional de Investigaciones Científicas y Técnicas
I. Alvarez Laboratorio de Virus Adventicios, Instituto de Virología e Innovaciones Tecnológicas (IVIT) CICVyA, INTA Castelar. Consejo Nacional de Investigaciones Científicas y Técnicas

DOI:

https://doi.org/10.30972/vet.3427058

Keywords:

Equine Parvovirus-Hepatitis, Theiler´s disease, biological products, contamination

Abstract

Equine Parvovirus-Hepatitis (EqPV-H) is a new member of Parvoviridae family discovered 5 years ago. This virus was first identified in the serum and liver of a horse that died of equine serum hepatitis, also known as Theiler’s disease. This disease is one of the most common causes of acute hepatitis and liver failure in horses and has been frequently described after the administration of a biological product of equine origin. Several reports in recent years strongly suggest that EqPV-H is the etiologic agent of Theiler’s disease. The infection is usually asymptomatic, so infected horses can be healthy carriers and serve as reservoirs for infection to other horses. EqPV-H infection has been detected in America, Europe, Asia and Oceania, with a DNA prevalence of 3.2-19.8% and a seroprevalence of 15-34% in clinically healthy horses, reaching values of 90-100% in animals with Theiler’s disease. EqPV-H DNA has also been detected in commercial equine serum pools, revealing the risk of transmission by biological products that use this serum in their manufacturing process. Recently, the Center for Veterinary Biologics of the United States Department of Agriculture requires that all commercially licensed equine serum or plasma biologicals be tested and confirmed negative for EqPV-H. These sanitary restrictions could also be implemented in other countries. This article summarizes the published knowledge to date on EqPV-H, a focus of rapidly evolving research.

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