Nefrotoxicidad inducida por AINEs: Reporte de caso

Luis Condolo; Jaime Javier Martínez Zambrano; Andrés Mancheno; Andrés Francisco Rodríguez Arévalo

doi:10.30972/vet.3719153

Authors

Luis Condolo Escuela Superior Politécnica de Chimborazo, Facultad de Ciencias Pecuarias, Carrera de Medicina Veterinaria. Panamericana Sur km 1 ½ Riobamba, Ecuador https://orcid.org/0000-0002-4811-116X
Jaime Javier Martínez Zambrano Escuela Superior Politécnica de Chimborazo, Facultad de Ciencias Pecuarias, Carrera de Medicina Veterinaria. Panamericana Sur km 1 ½ Riobamba, Ecuador. https://orcid.org/0009-0002-3033-993X
Andrés Mancheno Escuela Superior Politécnica de Chimborazo, Facultad de Ciencias Pecuarias, Carrera de Medicina Veterinaria. Panamericana Sur km 1 ½ Riobamba, Ecuador. https://orcid.org/0000-0002-2682-0336
Andrés Francisco Rodríguez Arévalo Universidad Regional Autónoma de los Andes, Facultad de Ciencias Médicas, Carrera de Medicina Veterinaria. Km 5 1/2 de la Vía a Baños, Ambato, Tungurahua, Ecuador. https://orcid.org/0009-0000-9871-5829

DOI:

https://doi.org/10.30972/vet.3719153

Keywords:

Acute kidney injury, ibuprofen, canine, therapy, diagnosis

Abstract

The use of human NSAID, such as ibuprofen, poses a critical risk in veterinary medicine due to their nephrotoxicity, frequently exacerbated by self-medication by pet owners. These drugs inhibit prostaglandins that regulate renal blood flow, causing severe damage, particularly at high doses or in dehydrated animals. This report presents the case of a 13-year-old male Golden Retriever that developed acute kidney injury (AKI) following ibuprofen administration, highlighting the importance of early diagnosis and appropriate clinical management. Treatment included fluid therapy and pharmacological agents aimed to alleviate clinical signs and restore renal function. It was concluded that, although the patient showed clinical improvement, NSAID-induced acute kidney injury in veterinary medicine requires continuous monitoring using specific biomarkers, which allows for early detection assessment of renal damage.

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